node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANY1 | PBR1 | YMR010W | YNL181W | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene. | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.551 |
ANY1 | PXP2 | YMR010W | YJR111C | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene. | Uncharacterized protein YJR111C; Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol. | 0.418 |
ANY1 | YLR352W | YMR010W | YLR352W | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene. | F-box protein YLR352W; Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene. | 0.489 |
ANY1 | YOR338W | YMR010W | YOR338W | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene. | Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication. | 0.521 |
BDH2 | PBR1 | YAL061W | YNL181W | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.617 |
BDH2 | YKL071W | YAL061W | YKL071W | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | Uncharacterized oxidoreductase YKL071W; Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | 0.554 |
CEM1 | PBR1 | YER061C | YNL181W | 3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.566 |
EMC6 | PBR1 | YLL014W | YNL181W | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93. | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.567 |
OYE3 | PBR1 | YPL171C | YNL181W | NADPH dehydrogenase 3; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death. | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.546 |
OYE3 | YKL071W | YPL171C | YKL071W | NADPH dehydrogenase 3; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death. | Uncharacterized oxidoreductase YKL071W; Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | 0.670 |
PBR1 | ANY1 | YNL181W | YMR010W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene. | 0.551 |
PBR1 | BDH2 | YNL181W | YAL061W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.617 |
PBR1 | CEM1 | YNL181W | YER061C | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.566 |
PBR1 | EMC6 | YNL181W | YLL014W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93. | 0.567 |
PBR1 | OYE3 | YNL181W | YPL171C | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | NADPH dehydrogenase 3; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death. | 0.546 |
PBR1 | PXP2 | YNL181W | YJR111C | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein YJR111C; Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol. | 0.655 |
PBR1 | YAL066W | YNL181W | YAL066W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative uncharacterized protein YAL066W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.634 |
PBR1 | YKL071W | YNL181W | YKL071W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized oxidoreductase YKL071W; Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | 0.571 |
PBR1 | YLR352W | YNL181W | YLR352W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | F-box protein YLR352W; Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene. | 0.722 |
PBR1 | YOR338W | YNL181W | YOR338W | Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication. | 0.706 |