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PRM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"PRM1" - Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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PRM1Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event (661 aa)    
Predicted Functional Partners:
FUS1
Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate; Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion (512 aa)
     
 
  0.937
AGA1
Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; Cell wall anchoring subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha- agglutinin, respectively, which interact with one another to promote cellular aggregation during mating (725 aa)
     
   
  0.804
FUS2
Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating; Promotes cell fusion during zygote formation (677 aa)
     
   
  0.764
FIG1
Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; Required for efficient mating (298 aa)
     
   
  0.708
ERG6
Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol (383 aa)
       
 
  0.646
STE12
Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid- specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids (688 aa)
     
 
  0.626
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols (222 aa)
       
 
  0.589
ERG3
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis (365 aa)
       
 
  0.582
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol (473 aa)
       
 
  0.568
SST2
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family; Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone (698 aa)
     
   
  0.520
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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