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KRE1 protein (Saccharomyces cerevisiae) - STRING interaction network
"KRE1" - Cell wall glycoprotein involved in beta-glucan assembly in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
co-expression
protein homology
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KRE1Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor; Involved in a late stage of cell wall 1,6-beta-glucan synthesis and assembly. Has a structural, rather than enzymic, function within cell wall 1,6-beta-glucan assembly and architecture, possibly by being involved in covalently cross- linking 1,6-beta-glucans to other cell wall components such as 1,3-beta-glucan, chitin and certain mannoproteins. Acts as the plasma membrane receptor for the yeast K1 viral toxin (313 aa)    
Predicted Functional Partners:
KRE6
Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; Involved in the synthesis of (1->6)- and (1->3)-beta-D- glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-struc [...] (720 aa)
       
 
  0.834
FLC2
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding (783 aa)
       
 
  0.825
ROT2
Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (954 aa)
       
 
  0.824
KRE9
Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects; Involved in cell wall beta(1->6) glucan synthesis (276 aa)
       
 
  0.820
KRE5
Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; Required for (1->6)-beta-D-glucan synthesis and normal cell growth (1365 aa)
       
 
  0.742
CWH41
Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed-9363442). Seems to play a role in beta-1,6- glucan synthesis (PubMed-8576053) (833 aa)
       
 
  0.740
DFG5
Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p; Required for normal synthesis of the cell wall (458 aa)
       
 
  0.723
SKN1
Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p; Required for synthesis of the major beta-glucans of the yeast cell wall (771 aa)
           
  0.697
KIC1
Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis; Protein kinase involved in morphogenesis and cell integrity (1080 aa)
       
 
  0.662
GAS1
Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non- reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3- beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis (559 aa)
       
 
  0.657
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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