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HOL1 protein (Saccharomyces cerevisiae) - STRING interaction network
"HOL1" - Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
co-expression
protein homology
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HOL1Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake; Seems to be involved in the uptake of several cations and of histidinol (586 aa)    
Predicted Functional Partners:
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; Probable transporter that confers resistance to short- chain monocarboxylic acids and quinidine (586 aa)
           
  0.829
QDR2
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake; Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro- 2-butynyl [3-chlorophenyl] carbamate). Implicated in potassium uptake (542 aa)
           
  0.829
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore (572 aa)
           
  0.829
FLR1
Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; Probable efflux transporter. Confers resistance to the azole derivative fluconazole (FCZ) (548 aa)
           
  0.829
QDR1
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban; Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole (563 aa)
           
  0.828
HIS4
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis (799 aa)
           
  0.549
STT3
Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that med [...] (718 aa)
           
  0.522
AMF1
Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug-H+ antiporters; YOR378W is not an essential gene; Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell (515 aa)
           
  0.504
YJL028W
Protein of unknown function; may interact with ribosomes, based on co-purification experiments (111 aa)
           
  0.441
YNL266W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C (139 aa)
           
  0.440
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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