node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRA1 | SDD3 | YLL029W | YOL098C | Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Belongs to the peptidase M24B family. | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.559 |
FRA1 | YFR006W | YLL029W | YFR006W | Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Belongs to the peptidase M24B family. | Uncharacterized peptidase YFR006W; Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene. | 0.803 |
LSO2 | RPL23A | YGR169C-A | YBL087C | Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication. | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | 0.865 |
LSO2 | SDD3 | YGR169C-A | YOL098C | Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication. | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.557 |
RPL23A | LSO2 | YBL087C | YGR169C-A | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication. | 0.865 |
RPL23A | SDD1 | YBL087C | YEL057C | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | 0.800 |
RPL23A | SDD2 | YBL087C | YMR074C | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | 0.591 |
RPL23A | SDD3 | YBL087C | YOL098C | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.740 |
RPL23A | YLR126C | YBL087C | YLR126C | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress. | 0.406 |
SDD1 | RPL23A | YEL057C | YBL087C | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | 0.800 |
SDD1 | SDD2 | YEL057C | YMR074C | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | 0.854 |
SDD1 | SDD3 | YEL057C | YOL098C | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.791 |
SDD1 | SDD4 | YEL057C | YPR022C | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.603 |
SDD2 | RPL23A | YMR074C | YBL087C | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | 0.591 |
SDD2 | SDD1 | YMR074C | YEL057C | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation. | 0.854 |
SDD2 | SDD3 | YMR074C | YOL098C | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.903 |
SDD2 | SDD4 | YMR074C | YPR022C | Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress. | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.830 |
SDD3 | FRA1 | YOL098C | YLL029W | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Belongs to the peptidase M24B family. | 0.559 |
SDD3 | LSO2 | YOL098C | YGR169C-A | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication. | 0.557 |
SDD3 | RPL23A | YOL098C | YBL087C | Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication. | 0.740 |