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RDS3 protein (Saccharomyces cerevisiae) - STRING interaction network
"RDS3" - Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance in Saccharomyces cerevisiae
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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RDS3Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance; Required for pre-mRNA splicing. Involved in regulation of drug sensitivity and may play a role in multidrug resistance (107 aa)    
Predicted Functional Partners:
YSF3
Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b; Involved in pre-mRNA splicing. Required for the SF3b integrity and prespliceosome assembly (85 aa)
     
  0.999
HSH155
U2-snRNP associated splicing factor; forms extensive associations with the branch site-3’ splice site-3’ exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly (971 aa)
       
  0.999
RSE1
Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; Involved in G2/M transition (By similarity). Required for pre-mRNA splicing and endoplasmic reticulum (ER) to Golgi secretion pathway. U2 snRNPs associated protein required for the pre-spliceosome assembly. The involvement in ER to Golgi secretion is probably indirect and due to the splicing of the pre-mRNA coding for SAR1, a small GTP-binding protein required for COPII vesicle formation from the ER (1361 aa)
       
  0.999
HSH49
U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); Possible SF3b-like factor (213 aa)
     
  0.997
CUS1
Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p; Essential splicing protein required for U2 snRNP binding to pre-mRNA during spliceosome assembly (436 aa)
       
  0.996
CEF1
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; Involved in pre-mRNA splicing and cell cycle control. Required for the binding of the NTC complex (or PRP19-associated complex) components to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Its absence leads to an arrest of the c [...] (590 aa)
       
      0.995
CWC2
Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled [...] (339 aa)
       
 
  0.985
IST3
Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; Required for pre-mRNA splicing and spliceosome assembly. As part of the pre-mRNA retention and splicing (RES) complex, required for nuclear pre-mRNA retention and efficient splicing. Required for MER1-activated splicing (148 aa)
     
 
  0.985
PRP2
RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16; Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleosid [...] (876 aa)
       
 
  0.975
BUD31
Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Involved in pre-mRNA splicing. Important for bud site selection (157 aa)
     
      0.974
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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