| node1 | node2 | node1 annotation | node2 annotation | score |
| XP_003679043.1 | XP_003679420.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | 0.849 |
| XP_003679043.1 | XP_003679638.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | 0.730 |
| XP_003679043.1 | XP_003680219.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family | 0.458 |
| XP_003679043.1 | XP_003680880.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] | 0.507 |
| XP_003679043.1 | XP_003681223.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Similar to Saccharomyces cerevisiae HHF1 (YBR009C); ancestral locus Anc_3.194 | 0.449 |
| XP_003679043.1 | XP_003682134.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Uncharacterized protein; Similar to Saccharomyces cerevisiae RLF2 (YPR018W); ancestral locus Anc_8.121 | 0.818 |
| XP_003679043.1 | XP_003682807.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.449 |
| XP_003679043.1 | XP_003683195.1 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly | 0.940 |
| XP_003679420.1 | XP_003679043.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | 0.849 |
| XP_003679420.1 | XP_003679638.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | 0.978 |
| XP_003679420.1 | XP_003680219.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family | 0.724 |
| XP_003679420.1 | XP_003680880.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] | 0.497 |
| XP_003679420.1 | XP_003681223.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Similar to Saccharomyces cerevisiae HHF1 (YBR009C); ancestral locus Anc_3.194 | 0.490 |
| XP_003679420.1 | XP_003682134.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Uncharacterized protein; Similar to Saccharomyces cerevisiae RLF2 (YPR018W); ancestral locus Anc_8.121 | 0.966 |
| XP_003679420.1 | XP_003682807.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.490 |
| XP_003679420.1 | XP_003683195.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | Histone chaperone; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly | 0.982 |
| XP_003679638.1 | XP_003679043.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle | 0.730 |
| XP_003679638.1 | XP_003679420.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | Uncharacterized protein; Similar to Saccharomyces cerevisiae CAC2 (YML102W); ancestral locus Anc_8.817 | 0.978 |
| XP_003679638.1 | XP_003680219.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family | 0.888 |
| XP_003679638.1 | XP_003680880.1 | Uncharacterized protein; Similar to Saccharomyces cerevisiae MSI1 (YBR195C); ancestral locus Anc_8.548 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] | 0.712 |
