Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication (500 aa)
Predicted Functional Partners:
DNA primase; Similar to Saccharomyces cerevisiae PRI1 (YIR008C); ancestral locus Anc_7.171; Belongs to the eukaryotic-type primase small subunit family (416 aa)
DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (666 aa)
DNA polymerase; Similar to Saccharomyces cerevisiae POL1 (YNL102W); ancestral locus Anc_2.176 (1448 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae POL2 (YNL262W); ancestral locus Anc_1.94 (2211 aa)
DNA helicase; Similar to Saccharomyces cerevisiae CDC46 (YLR274W); ancestral locus Anc_6.71; Belongs to the MCM family (755 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae CTF4 (YPR135W); ancestral locus Anc_3.473 (917 aa)
DNA polymerase; Similar to Saccharomyces cerevisiae POL3 (YDL102W); ancestral locus Anc_2.351 (1094 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae DPB2 (YPR175W); ancestral locus Anc_7.532 (687 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae POL31 (YJR006W); ancestral locus Anc_5.175 (461 aa)
DNA helicase; Similar to Saccharomyces cerevisiae MCM2 (YBL023C); ancestral locus Anc_8.170; Belongs to the MCM family (873 aa)