Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Groups of genes that are frequently observed in each other's genomic neighborhood.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
PRA1 family protein; Similar to Saccharomyces cerevisiae YIP3 (YNL044W); ancestral locus Anc_2.269 (176 aa)
Predicted Functional Partners:
Reticulon-like protein; Similar to Saccharomyces cerevisiae RTN2 (YDL204W) and RTN1 (YDR233C); ancestral locus Anc_8.454 (293 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae SEC6 (YIL068C); ancestral locus Anc_7.258 (796 aa)
Protein YIP; Similar to Saccharomyces cerevisiae YIP4 (YGL198W); ancestral locus Anc_8.158 (224 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae YPT1 (YFL038C); ancestral locus Anc_8.25 (208 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae YIF1 (YNL263C); ancestral locus Anc_1.93 (307 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae RPS31 (YLR167W); ancestral locus Anc_8.386 (150 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae YOS1 (YER074W-A); ancestral locus Anc_7.263 (84 aa)
Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (295 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae YIP5 (YGL161C); ancestral locus Anc_8.110 (294 aa)
Protein YIP; Similar to Saccharomyces cerevisiae YIP1 (YGR172C); ancestral locus Anc_5.177 (245 aa)