Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Uncharacterized protein; Similar to Saccharomyces cerevisiae YIL108W; ancestral locus Anc_2.263 (690 aa)
Predicted Functional Partners:
Uncharacterized protein; Similar to Saccharomyces cerevisiae YER034W; ancestral locus Anc_3.532 (184 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae BOP3 (YNL042W); ancestral locus Anc_2.270 (327 aa)
CDP-diacylglycerol--serine O-phosphatidyltransferase; Similar to Saccharomyces cerevisiae CHO1 (YER026C); ancestral locus Anc_3.513; Belongs to the CDP-alcohol phosphatidyltransferase class-I family (274 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae SLM5 (YCR024C); ancestral locus Anc_1.449 (485 aa)