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CTU1 protein (Torulaspora delbrueckii) - STRING interaction network
"CTU1" - Hypothetical protein in Torulaspora delbrueckii
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CTU1Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (378 aa)    
Predicted Functional Partners:
CTU2
Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (472 aa)
     
  0.995
URM1
Hypothetical protein; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2- thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target protein [...] (98 aa)
       
  0.765
XP_003679050.1
Hypothetical protein (561 aa)
     
 
  0.703
XP_003679726.1
Hypothetical protein (552 aa)
   
 
  0.702
XP_003679213.1
Hypothetical protein (1897 aa)
   
   
  0.691
XP_003682436.1
Hypothetical protein; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1587 aa)
     
 
  0.690
UBA4
Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl- adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfi [...] (437 aa)
     
 
  0.620
XP_003682303.1
Hypothetical protein (497 aa)
     
  0.568
XP_003683347.1
Hypothetical protein (744 aa)
     
 
  0.540
XP_003681048.1
Hypothetical protein (452 aa)
     
 
  0.540
Your Current Organism:
Torulaspora delbrueckii
NCBI taxonomy Id: 4950
Other names: Candida colliculosa, Saccharomyces fermentati, Saccharomyces rosei, T. delbrueckii, Torulaspora, Torulaspora delbrueckii
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