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UBA4 protein (Torulaspora delbrueckii) - STRING interaction network
"UBA4" - Hypothetical protein in Torulaspora delbrueckii
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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UBA4Hypothetical protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl- adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfi [...] (437 aa)    
Predicted Functional Partners:
XP_003679941.1
Hypothetical protein (496 aa)
   
  0.967
URM1
Hypothetical protein; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2- thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target protein [...] (98 aa)
       
  0.965
XP_003679179.1
Hypothetical protein (304 aa)
     
  0.949
XP_003681121.1
Hypothetical protein (289 aa)
     
  0.883
XP_003682939.1
Hypothetical protein (169 aa)
       
  0.880
XP_003682521.1
Hypothetical protein (217 aa)
       
  0.880
XP_003682232.1
Hypothetical protein (147 aa)
       
  0.880
XP_003681576.1
Hypothetical protein (157 aa)
       
  0.880
XP_003681358.1
Hypothetical protein (150 aa)
       
  0.880
XP_003678677.1
Hypothetical protein (157 aa)
       
  0.880
Your Current Organism:
Torulaspora delbrueckii
NCBI taxonomy Id: 4950
Other names: Candida colliculosa, Saccharomyces fermentati, Saccharomyces rosei, T. delbrueckii, Torulaspora, Torulaspora delbrueckii
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