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GET1 protein (Torulaspora delbrueckii) - STRING interaction network
"GET1" - Golgi to ER traffic protein 1 in Torulaspora delbrueckii
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GET1Golgi to ER traffic protein 1; Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (224 aa)    
Predicted Functional Partners:
GET3
ATPase GET3; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (353 aa)
     
 
  0.991
XP_003680443.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae ERD2 (YBL040C); ancestral locus Anc_7.479 (217 aa)
           
  0.926
GET2
Golgi to ER traffic protein 2; Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (310 aa)
       
 
  0.925
XP_003682991.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae YOR164C; ancestral locus Anc_6.57 (306 aa)
       
 
  0.925
XP_003681528.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae MDY2 (YOL111C); ancestral locus Anc_3.65 (197 aa)
       
 
  0.903
XP_003683026.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae SGT2 (YOR007C); ancestral locus Anc_6.21 (343 aa)
       
 
  0.765
XP_003678738.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae SED5 (YLR026C); ancestral locus Anc_2.421; Belongs to the syntaxin family (309 aa)
       
 
  0.673
XP_003682986.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae SEC22 (YLR268W); ancestral locus Anc_6.62; Belongs to the synaptobrevin family (214 aa)
     
 
  0.663
XP_003680278.1
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum (88 aa)
     
 
  0.628
XP_003680148.1
Uncharacterized protein; Similar to Saccharomyces cerevisiae YLR065C; ancestral locus Anc_8.24 (178 aa)
       
 
  0.618
Your Current Organism:
Torulaspora delbrueckii
NCBI taxonomy Id: 4950
Other names: Candida colliculosa, Saccharomyces delbrueckii, Saccharomyces fermentati, Saccharomyces rosei, T. delbrueckii, Torulaspora delbrueckii, Torulaspora sp. R3DFM2, WM 821
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