Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Potassium transport protein; Similar to Saccharomyces cerevisiae TRK1 (YJL129C) and TRK2 (YKR050W); ancestral locus Anc_1.224; Belongs to the TrkH potassium transport family (1213 aa)
Predicted Functional Partners:
Uncharacterized protein; Similar to Saccharomyces cerevisiae NHA1 (YLR138W); ancestral locus Anc_8.341 (956 aa)
Serine/threonine-protein phosphatase; Similar to Saccharomyces cerevisiae PPZ2 (YDR436W) and PPZ1 (YML016C); ancestral locus Anc_5.548 (674 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae KHA1 (YJL094C); ancestral locus Anc_1.272 (869 aa)
Sodium/hydrogen exchanger; Similar to Saccharomyces cerevisiae NHX1 (YDR456W); ancestral locus Anc_5.573; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family (625 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae TOK1 (YJL093C); ancestral locus Anc_1.273; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family (668 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae SAT4 (YCR008W); ancestral locus Anc_1.423 (575 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae YJR054W and PRM6 (YML047C); ancestral locus Anc_1.495 (423 aa)
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (944 aa)
Uncharacterized protein; Similar to Saccharomyces cerevisiae VNX1 (YNL321W); ancestral locus Anc_3.19; Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family (938 aa)
Plasma membrane ATPase; Similar to Saccharomyces cerevisiae PMA1 (YGL008C); ancestral locus Anc_4.115 (906 aa)