STRINGSTRING
THI4 protein (Yarrowia lipolytica) - STRING interaction network
"THI4" - YALI0A09768p in Yarrowia lipolytica
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THI4YALI0A09768p; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (317 aa)    
Predicted Functional Partners:
XP_503531.1
YALI0E04224p (513 aa)
         
  0.639
XP_500551.2
YALI0B05940p (3277 aa)
       
 
  0.546
XP_501873.1
YALI0C15554p (511 aa)
   
   
  0.535
XP_503861.1
YALI0E12397p (306 aa)
           
  0.441
XP_500584.1
YALI0B06853p (779 aa)
           
  0.439
XP_504226.1
YALI0E21351p (250 aa)
           
  0.438
XP_503213.1
YALI0D23969p; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (1537 aa)
           
  0.428
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 4952
Other names: Candida lipolytica, Dipodascaceae, Mycotorula lipolytica, Y. lipolytica, Yarrowia, Yarrowia lipolytica
Server load: low (7%) [HD]