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PAN3 protein (Yarrowia lipolytica) - STRING interaction network
"PAN3" - YALI0C14256p in Yarrowia lipolytica
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PAN3YALI0C14256p; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. May al [...] (670 aa)    
Predicted Functional Partners:
PAN2
YALI0E29403p; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. May als [...] (891 aa)
     
  0.998
REX4
YALI0B18128p; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity) (291 aa)
     
  0.860
XP_500929.1
YALI0B15400p (630 aa)
     
  0.860
REX3
YALI0B07689p; 3’ to 5’ exoribonuclease required for proper 3’ end maturation of MRP RNA and of the U5L snRNA (757 aa)
     
  0.860
XP_002143012.1
YALI0B10824p (184 aa)
     
  0.860
PAB1
YALI0C00539p; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation t [...] (629 aa)
       
  0.809
XP_500351.1
YALI0B00616p (589 aa)
       
  0.591
XP_503225.1
YALI0D24299p (255 aa)
       
    0.546
TIF1
YALI0B20922p; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity) (395 aa)
         
  0.528
FAL1
YALI0F02695p; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity) (397 aa)
         
    0.526
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 4952
Other names: Candida lipolytica, Dipodascaceae, Mycotorula lipolytica, Y. lipolytica, Yarrowia, Yarrowia lipolytica
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