STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POL2DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2183 aa)    
Predicted Functional Partners:
DPB2
DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family.
  
 0.999
DPB4
DNA polymerase epsilon subunit D; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
   
 0.999
YALI0_F04664g
DNA helicase; Belongs to the MCM family.
   
 0.997
YALI0_A01353g
DNA helicase; Belongs to the MCM family.
   
 0.995
YALI0_E11869g
DNA polymerase.
   
 0.991
YALI0_F04818g
DNA helicase; Belongs to the MCM family.
   
 0.990
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 0.990
YALI0_F04576g
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.
   
 0.989
YALI0_B06369g
YALI0B06369p.
   
 0.989
YALI0_F21945g
DNA helicase; Belongs to the MCM family.
   
 0.988
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.