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PAN2 protein (Yarrowia lipolytica) - STRING interaction network
"PAN2" - YALI0E29403p in Yarrowia lipolytica
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PAN2YALI0E29403p; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. May als [...] (891 aa)    
Predicted Functional Partners:
PAN3
YALI0C14256p; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3’ exonucleolytic degradation by XRN1. May al [...] (670 aa)
     
  0.998
XP_502661.1
YALI0D10571p; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (264 aa)
     
  0.849
PAB1
YALI0C00539p; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation t [...] (629 aa)
       
  0.733
XP_500778.1
Ribosome biogenesis protein BRX1 (286 aa)
     
        0.689
ARO1
YALI0F12639p; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1556 aa)
         
  0.673
CCR4
YALI0B15147p; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3’-5’ RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity) (705 aa)
     
 
  0.662
XP_500001.1
YALI0A12067p (206 aa)
     
      0.645
XP_500351.1
YALI0B00616p (589 aa)
       
  0.631
YTM1
YALI0B12320p; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (511 aa)
     
        0.615
XP_501809.1
YALI0C13882p (434 aa)
     
        0.611
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 4952
Other names: Candida lipolytica, Dipodascaceae, Mycotorula lipolytica, Y. lipolytica, Yarrowia, Yarrowia lipolytica
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