STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIL1Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Probably functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. It is not required for viability but is essential for optimal growth at elevated temperatures. Belongs to the SIL1 family. (426 aa)    
Predicted Functional Partners:
YALI0_E13277g
YALI0E13277p.
   
 
 0.991
KAR2
Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family.
   
 
 0.991
YALI0_B04334g
YALI0B04334p.
   
 
 0.990
YALI0_B08778g
YALI0B08778p.
   
 0.956
SEC61
Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
  
 
 0.947
YALI0_F25531g
YALI0F25531p; Belongs to the universal ribosomal protein uL23 family.
  
 0.923
YALI0_E22352g
YALI0E22352p.
  
 0.922
YALI0_B21076g
YALI0B21076p; Belongs to the universal ribosomal protein uL15 family.
  
 0.922
RPL7
60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family.
  
 0.919
YALI0_E21219g
YALI0E21219p.
  
 0.899
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122
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