node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KAR2 | SEC61 | Q99170 | P78979 | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | 0.926 |
KAR2 | SIL1 | Q99170 | Q99158 | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Probably functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. It is not required for viability but is essential for optimal growth at elevated temperatures. Belongs to the SIL1 family. | 0.991 |
KAR2 | YALI0_B04334g | Q99170 | Q6CFS2 | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | YALI0B04334p. | 0.672 |
KAR2 | YALI0_B08778g | Q99170 | Q6CFA8 | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | YALI0B08778p. | 0.988 |
KAR2 | YALI0_E13277g | Q99170 | Q6C617 | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | YALI0E13277p. | 0.703 |
RPL7 | SEC61 | Q6C603 | P78979 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | 0.973 |
RPL7 | SIL1 | Q6C603 | Q99158 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Probably functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. It is not required for viability but is essential for optimal growth at elevated temperatures. Belongs to the SIL1 family. | 0.919 |
RPL7 | YALI0_B04334g | Q6C603 | Q6CFS2 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0B04334p. | 0.996 |
RPL7 | YALI0_B21076g | Q6C603 | Q6CDU7 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0B21076p; Belongs to the universal ribosomal protein uL15 family. | 0.999 |
RPL7 | YALI0_E13277g | Q6C603 | Q6C617 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0E13277p. | 0.993 |
RPL7 | YALI0_E21219g | Q6C603 | Q6C540 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0E21219p. | 0.999 |
RPL7 | YALI0_E22352g | Q6C603 | Q6C4Z8 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0E22352p. | 0.999 |
RPL7 | YALI0_F25531g | Q6C603 | Q6C0E1 | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | YALI0F25531p; Belongs to the universal ribosomal protein uL23 family. | 0.999 |
SEC61 | KAR2 | P78979 | Q99170 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis; Belongs to the heat shock protein 70 family. | 0.926 |
SEC61 | RPL7 | P78979 | Q6C603 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | 60S ribosomal protein L7; Belongs to the universal ribosomal protein uL30 family. | 0.973 |
SEC61 | SIL1 | P78979 | Q99158 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Probably functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. It is not required for viability but is essential for optimal growth at elevated temperatures. Belongs to the SIL1 family. | 0.947 |
SEC61 | YALI0_B08778g | P78979 | Q6CFA8 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | YALI0B08778p. | 0.576 |
SEC61 | YALI0_B21076g | P78979 | Q6CDU7 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | YALI0B21076p; Belongs to the universal ribosomal protein uL15 family. | 0.973 |
SEC61 | YALI0_E21219g | P78979 | Q6C540 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | YALI0E21219p. | 0.974 |
SEC61 | YALI0_E22352g | P78979 | Q6C4Z8 | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | YALI0E22352p. | 0.973 |