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GET3 protein (Yarrowia lipolytica) - STRING interaction network
"GET3" - YALI0E33495p in Yarrowia lipolytica
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GET3YALI0E33495p; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (327 aa)    
Predicted Functional Partners:
XP_502817.1
YALI0D14344p (304 aa)
       
 
  0.957
GET1
YALI0E20889p; Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (224 aa)
       
 
  0.941
XP_502899.1
YALI0D16401p (359 aa)
       
 
  0.766
SEC61
YALI0E21912p; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity) (471 aa)
     
  0.722
XP_501637.1
YALI0C09328p (344 aa)
     
 
  0.634
XP_503158.2
YALI0D22594p (471 aa)
     
  0.631
XP_501920.1
YALI0C16819p (306 aa)
       
 
  0.606
SBH1
YALI0F08481p; Necessary for protein translocation in the endoplasmic reticulum (91 aa)
     
  0.581
XP_002143050.1
YALI0D08635p (68 aa)
     
 
  0.580
SEC62
YALI0B17512p; Required for preprotein translocation (396 aa)
     
  0.575
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 4952
Other names: Candida lipolytica, Dipodascaceae, Mycotorula lipolytica, Y. lipolytica, Yarrowia, Yarrowia lipolytica
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