STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C5DWA5_ZYGRCHistone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (577 aa)    
Predicted Functional Partners:
C5DZQ8_ZYGRC
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
   
 0.972
C5E179_ZYGRC
ZYRO0G18766p; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
   
 0.968
C5DXT8_ZYGRC
ZYRO0F07722p.
   
 0.940
C5DPC3_ZYGRC
Histone H3; Belongs to the histone H3 family.
   
 0.930
C5DX03_ZYGRC
ZYRO0F01144p.
   
 0.902
C5DY24_ZYGRC
ZYRO0F09680p.
     
  0.900
C5DPC4_ZYGRC
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.899
C5DZW9_ZYGRC
ZYRO0G07854p.
   
   0.879
C5DSY8_ZYGRC
ZYRO0C04026p.
   
   0.877
C5DVB8_ZYGRC
ZYRO0D05434p.
   
 0.786
Your Current Organism:
Zygosaccharomyces rouxii
NCBI taxonomy Id: 559307
Other names: Z. rouxii CBS 732, Zygosaccharomyces rouxii CBS 732
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.