STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBC6Ubiquitin-conjugating enzyme E2 6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. (242 aa)    
Predicted Functional Partners:
Q6BZC0_DEBHA
DEHA2A02530p; Belongs to the ubiquitin-conjugating enzyme family.
    
0.978
B5RTT0_DEBHA
DEHA2E02222p.
  
  
 
0.910
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]
    
 0.740
Q6BX27_DEBHA
DEHA2B06512p; Belongs to the ubiquitin-conjugating enzyme family.
     
 0.710
Q6BL12_DEBHA
DEHA2F17204p; Belongs to the ubiquitin-activating E1 family.
    
 0.700
Q6BQX4_DEBHA
DEHA2E01562p; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.682
Q6BJ52_DEBHA
DEHA2G05126p.
   
 0.665
Q6BSY0_DEBHA
DEHA2D05148p.
     
 0.660
Q6BVE8_DEBHA
DEHA2C03168p; Belongs to the ubiquitin-conjugating enzyme family.
   
0.642
Q6BMT3_DEBHA
DEHA2F02816p.
    
 0.638
Your Current Organism:
Debaryomyces hansenii
NCBI taxonomy Id: 284592
Other names: D. hansenii CBS767, Debaryomyces hansenii CBS767
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.