STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
CIA1Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins (394 aa)    
Predicted Functional Partners:
XP_457222.2
DEHA2B06006p; Similar to uniprot|P38829 Saccharomyces cerevisiae YHR122w protein required for cell viability
   
 
 0.964
XP_456729.2
DEHA2A09196p; Weakly similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator
   
 
 0.951
NAR1
Cytosolic Fe-S cluster assembly factor NAR1; Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity)
   
 
 0.819
DRE2
Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death
      
 0.748
TAH18
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the N-terminal section; belongs to the flavodoxin family
      
 0.714
CFD1
Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD [...]
 
 
 
 0.705
NBP35
Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NB [...]
 
 
 
 0.655
ATM1
Iron-sulfur clusters transporter ATM1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity)
   
  
 0.618
XP_459459.1
DEHA2E02992p; Similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A; Belongs to the complex I LYR family
   
  
 0.615
XP_459290.1
DEHA2D18524p; Similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm
 
 
 
 0.614
Your Current Organism:
Debaryomyces hansenii
NCBI taxonomy Id: 4959
Other names: ATCC 36239, CBS 767, CCRC 21394, D. hansenii, DBVPG 6050, Debaryomyces hansenii, Debaryomyces sp. ZIM 2431, Debaryomyces tyrocola var. hansenii, IFO 0083, JCM 2101, KCTC 7645, MUCL 30242, NCYC 2572, NRRL Y-10976, NRRL Y-7426, Pichia hansenii, Saccharomyces hansenii, Torulaspora hansenii, UCD 74-86
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