node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HM1_2435 | clpB | HM1_2435 | HM1_1340 | Thermosome subunit. | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.640 |
HM1_2435 | clpC | HM1_2435 | HM1_1344 | Thermosome subunit. | Member of ATPase family associated with various cellular activities (AAA) PFAM, PF07724; Belongs to the ClpA/ClpB family. | 0.640 |
HM1_2435 | clpP | HM1_2435 | HM1_0471 | Thermosome subunit. | ATP-dependent clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.483 |
HM1_2435 | clpX | HM1_2435 | HM1_0472 | Thermosome subunit. | ATP-dependent clp protease, ATP-binding subunit clpx; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.426 |
HM1_2435 | dnaK | HM1_2435 | HM1_2437 | Thermosome subunit. | Chaperone protein dnak; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.957 |
HM1_2435 | grpE | HM1_2435 | HM1_2436 | Thermosome subunit. | Co-chaperone grpe; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.985 |
HM1_2435 | hslU | HM1_2435 | HM1_2215 | Thermosome subunit. | Heat shock protein hslvu, ATPase subunit hslu; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.779 |
HM1_2435 | hslV | HM1_2435 | HM1_2214 | Thermosome subunit. | ATP-dependent protease hslv; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.666 |
HM1_2435 | lonA | HM1_2435 | HM1_0474 | Thermosome subunit. | ATP-dependent protease la; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.692 |
clpB | HM1_2435 | HM1_1340 | HM1_2435 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Thermosome subunit. | 0.640 |
clpB | clpP | HM1_1340 | HM1_0471 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.803 |
clpB | clpX | HM1_1340 | HM1_0472 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent clp protease, ATP-binding subunit clpx; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.451 |
clpB | dnaK | HM1_1340 | HM1_2437 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein dnak; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.904 |
clpB | groEL | HM1_1340 | HM1_1422 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin groel; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.640 |
clpB | grpE | HM1_1340 | HM1_2436 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperone grpe; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.918 |
clpB | hslU | HM1_1340 | HM1_2215 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein hslvu, ATPase subunit hslu; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.587 |
clpB | hslV | HM1_1340 | HM1_2214 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease hslv; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.448 |
clpB | lonA | HM1_1340 | HM1_0474 | Chaperone clpb; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease la; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.713 |
clpC | HM1_2435 | HM1_1344 | HM1_2435 | Member of ATPase family associated with various cellular activities (AAA) PFAM, PF07724; Belongs to the ClpA/ClpB family. | Thermosome subunit. | 0.640 |
clpC | clpP | HM1_1344 | HM1_0471 | Member of ATPase family associated with various cellular activities (AAA) PFAM, PF07724; Belongs to the ClpA/ClpB family. | ATP-dependent clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.827 |