node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HM1_1721 | HM1_1889 | HM1_1721 | HM1_1889 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Methenyltetrahydrofolate cyclohydrolase, putative. | 0.505 |
HM1_1721 | fhs | HM1_1721 | HM1_0672 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.948 |
HM1_1721 | folD | HM1_1721 | HM1_1888 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.514 |
HM1_1721 | glyA | HM1_1721 | HM1_1090 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
HM1_1721 | metH | HM1_1721 | HM1_2499 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Methionine synthase, putative; Contains B12 binding domains. | 0.949 |
HM1_1721 | purH | HM1_1721 | HM1_3106 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Bifunctional purine biosynthesis protein. | 0.900 |
HM1_1721 | purN | HM1_1721 | HM1_3107 | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
HM1_1889 | HM1_1721 | HM1_1889 | HM1_1721 | Methenyltetrahydrofolate cyclohydrolase, putative. | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | 0.505 |
HM1_1889 | fhs | HM1_1889 | HM1_0672 | Methenyltetrahydrofolate cyclohydrolase, putative. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.965 |
HM1_1889 | folD | HM1_1889 | HM1_1888 | Methenyltetrahydrofolate cyclohydrolase, putative. | Tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
HM1_1889 | purH | HM1_1889 | HM1_3106 | Methenyltetrahydrofolate cyclohydrolase, putative. | Bifunctional purine biosynthesis protein. | 0.903 |
HM1_1889 | purN | HM1_1889 | HM1_3107 | Methenyltetrahydrofolate cyclohydrolase, putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
fhs | HM1_1721 | HM1_0672 | HM1_1721 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydrofolate--homocysteine s-methyltransferase, putative; Matches pterin binding enzyme domain, PF00809. | 0.948 |
fhs | HM1_1889 | HM1_0672 | HM1_1889 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase, putative. | 0.965 |
fhs | folD | HM1_0672 | HM1_1888 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | glyA | HM1_0672 | HM1_1090 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
fhs | metH | HM1_0672 | HM1_2499 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase, putative; Contains B12 binding domains. | 0.956 |
fhs | purC | HM1_0672 | HM1_3111 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.837 |
fhs | purF | HM1_0672 | HM1_3109 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.806 |
fhs | purH | HM1_0672 | HM1_3106 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein. | 0.985 |