node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HM1_1519 | HM1_2993 | HM1_1519 | HM1_2993 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.921 |
HM1_1519 | ilvC | HM1_1519 | HM1_1513 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.819 |
HM1_1519 | ilvD | HM1_1519 | HM1_1511 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.973 |
HM1_1519 | leuA | HM1_1519 | HM1_1515 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.930 |
HM1_1519 | leuB | HM1_1519 | HM1_1518 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.903 |
HM1_1519 | leuC | HM1_1519 | HM1_1516 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.983 |
HM1_1519 | leuD | HM1_1519 | HM1_1517 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.983 |
HM1_1519 | oadA | HM1_1519 | HM1_0282 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Oxaloacetate decarboxylase, alpha subunit; Also has gene sym pycB. | 0.813 |
HM1_1519 | pykA | HM1_1519 | HM1_0076 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.809 |
HM1_1519 | pykA-2 | HM1_1519 | HM1_1600 | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.809 |
HM1_2993 | HM1_1519 | HM1_2993 | HM1_1519 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.921 |
HM1_2993 | ilvC | HM1_2993 | HM1_1513 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.795 |
HM1_2993 | ilvD | HM1_2993 | HM1_1511 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.756 |
HM1_2993 | leuA | HM1_2993 | HM1_1515 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.914 |
HM1_2993 | leuB | HM1_2993 | HM1_1518 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.895 |
HM1_2993 | leuC | HM1_2993 | HM1_1516 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.834 |
HM1_2993 | leuD | HM1_2993 | HM1_1517 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.834 |
ilvC | HM1_1519 | HM1_1513 | HM1_1519 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase/homocitrate synthase family protein, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.819 |
ilvC | HM1_2993 | HM1_1513 | HM1_2993 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.795 |
ilvC | ilvD | HM1_1513 | HM1_1511 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.998 |