STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
surEAcid phosphatase sure; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (272 aa)    
Predicted Functional Partners:
guaA
Gmp synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
 0.964
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.953
cmk
Cytidylate kinase.
    
 0.937
pyrR
Pyrr bifunctional protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
     
 0.931
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
     
 0.931
purH
Bifunctional purine biosynthesis protein.
     
 0.931
cinA
Competence/damage-inducible protein cina, putative; Belongs to the CinA family.
    
  0.928
purB
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.925
pdp
Pyrimidine-nucleoside phosphorylase.
    
 0.923
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
    
 0.921
Your Current Organism:
Heliobacterium modesticaldum
NCBI taxonomy Id: 498761
Other names: H. modesticaldum Ice1, Heliobacterium modesticaldum Ice1, Heliobacterium modesticaldum str. Ice1, Heliobacterium modesticaldum strain Ice1
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