node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HM1_2671 | HM1_2674 | HM1_2671 | HM1_2674 | Gluconate permease. | Transcriptional regulator, deor family. | 0.634 |
HM1_2671 | denK | HM1_2671 | HM1_2673 | Gluconate permease. | Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4- hydroxy-L-threonine, with lower efficiency. | 0.906 |
HM1_2671 | pdxA | HM1_2671 | HM1_2672 | Gluconate permease. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.879 |
HM1_2674 | HM1_2671 | HM1_2674 | HM1_2671 | Transcriptional regulator, deor family. | Gluconate permease. | 0.634 |
HM1_2674 | denK | HM1_2674 | HM1_2673 | Transcriptional regulator, deor family. | Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4- hydroxy-L-threonine, with lower efficiency. | 0.824 |
HM1_2674 | pdxA | HM1_2674 | HM1_2672 | Transcriptional regulator, deor family. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.748 |
dapA | pdxA | HM1_2332 | HM1_2672 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.687 |
denK | HM1_2671 | HM1_2673 | HM1_2671 | Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4- hydroxy-L-threonine, with lower efficiency. | Gluconate permease. | 0.906 |
denK | HM1_2674 | HM1_2673 | HM1_2674 | Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4- hydroxy-L-threonine, with lower efficiency. | Transcriptional regulator, deor family. | 0.824 |
denK | pdxA | HM1_2673 | HM1_2672 | Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-erythronate to D-erythronate 4-phosphate. Can also phosphorylate D-threonate and 4- hydroxy-L-threonine, with lower efficiency. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.993 |
folB | pdxA | HM1_0669 | HM1_2672 | Folate synthesis, bifunctional protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.491 |
folB | ribAB | HM1_0669 | HM1_2143 | Folate synthesis, bifunctional protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis family protein ribab; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.662 |
folB | ribD | HM1_0669 | HM1_2141 | Folate synthesis, bifunctional protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.758 |
folB | serC | HM1_0669 | HM1_2036 | Folate synthesis, bifunctional protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.467 |
gyrB | pdxA | HM1_0901 | HM1_2672 | DNA gyrase, b subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.828 |
gyrB | ribD | HM1_0901 | HM1_2141 | DNA gyrase, b subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.481 |
ksgA | pdxA | HM1_0743 | HM1_2672 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | 0.750 |
pdxA | HM1_2671 | HM1_2672 | HM1_2671 | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | Gluconate permease. | 0.879 |
pdxA | HM1_2674 | HM1_2672 | HM1_2674 | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | Transcriptional regulator, deor family. | 0.748 |
pdxA | dapA | HM1_2672 | HM1_2332 | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use D-threonate 4-phosphate as substrate. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.687 |