node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HM1_2699 | aroE | HM1_2699 | HM1_0245 | Conserved hypothetical protein. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.600 |
HM1_2699 | nadD | HM1_2699 | HM1_2701 | Conserved hypothetical protein. | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.991 |
HM1_2699 | obg | HM1_2699 | HM1_2705 | Conserved hypothetical protein. | Spo0b-associated GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.410 |
HM1_2699 | rsfS | HM1_2699 | HM1_2698 | Conserved hypothetical protein. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.927 |
aroE | HM1_2699 | HM1_0245 | HM1_2699 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein. | 0.600 |
aroE | nadD | HM1_0245 | HM1_2701 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.764 |
cinA | nadC | HM1_2373 | HM1_0664 | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.951 |
cinA | nadD | HM1_2373 | HM1_2701 | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.968 |
cinA | nadE | HM1_2373 | HM1_2802 | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | Nad+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.656 |
cinA | rsfS | HM1_2373 | HM1_2698 | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.465 |
cinA | surE | HM1_2373 | HM1_2558 | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | Acid phosphatase sure; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.928 |
nadC | cinA | HM1_0664 | HM1_2373 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | 0.951 |
nadC | nadD | HM1_0664 | HM1_2701 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.948 |
nadC | nadE | HM1_0664 | HM1_2802 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | Nad+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.626 |
nadC | ribD | HM1_0664 | HM1_2141 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.585 |
nadC | surE | HM1_0664 | HM1_2558 | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | Acid phosphatase sure; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.904 |
nadD | HM1_2699 | HM1_2701 | HM1_2699 | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein. | 0.991 |
nadD | aroE | HM1_2701 | HM1_0245 | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.764 |
nadD | cinA | HM1_2701 | HM1_2373 | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Competence/damage-inducible protein cina, putative; Belongs to the CinA family. | 0.968 |
nadD | nadC | HM1_2701 | HM1_0664 | Nicotinate nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.948 |