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hisF protein (Heliobacterium modesticaldum) - STRING interaction network
"hisF" - Imidazole glycerol phosphate synthase subunit HisF in Heliobacterium modesticaldum
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Predicted Interactions
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textmining
co-expression
protein homology
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hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (261 aa)    
Predicted Functional Partners:
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (204 aa)
  0.999
hisI
Histidine biosynthesis bifunctional protein HisIE; Also matches phosphoribosyl-ATP pyrophosphohydrolase equivalog domain, PF01503, EC number 3.6.1.31; In the N-terminal section; belongs to the PRA-CH family (225 aa)
   
  0.999
hisB
annotation not available (195 aa)
  0.999
hisA
annotation not available (245 aa)
 
 
0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (426 aa)
 
  0.996
hisC
annotation not available (418 aa)
 
  0.991
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Short subfamily (219 aa)
 
 
  0.987
cobD
annotation not available (374 aa)
 
 
  0.889
purH
annotation not available (527 aa)
   
 
    0.888
trpE
Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (516 aa)
 
   
  0.873
Your Current Organism:
Heliobacterium modesticaldum
NCBI taxonomy Id: 498761
Other names: H. modesticaldum Ice1, Heliobacterium modesticaldum, Heliobacterium modesticaldum Ice1, Heliobacterium modesticaldum str. Ice1, Heliobacterium modesticaldum strain Ice1
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