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Slin_1051 protein (Spirosoma linguale) - STRING interaction network
"Slin_1051" - Dihydrofolate reductase in Spirosoma linguale
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Slin_1051Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (264 aa)
 
  0.998
fmt
methionyl-tRNA formyltransferase; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (312 aa)
   
 
  0.946
Slin_1996
Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase (428 aa)
   
  0.943
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (428 aa)
   
  0.933
Slin_4250
Methionine synthase (1261 aa)
   
 
  0.914
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine (364 aa)
   
 
  0.912
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (517 aa)
     
    0.910
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (193 aa)
     
 
  0.902
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (306 aa)
         
  0.900
Slin_4404
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (159 aa)
 
   
  0.871
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale, S. linguale DSM 74, Spirosoma, Spirosoma linguale, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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