"Slin_4404" - 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase in
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Groups of genes that are frequently observed in each other's genomic neighborhood.
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Genes that are sometimes fused into single open reading frames.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Gene families whose occurrence patterns across genomes show similarities.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
query proteins and first shell of interactors
second shell of interactors
proteins of unknown 3D structure
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (159 aa)
Predicted Functional Partners:
Dihydropteroate synthase (286 aa)
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin (116 aa)
GTP cyclohydrolase I (241 aa)
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)
Hypothetical protein (334 aa)
Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase (428 aa)
Hypothetical protein (123 aa)
Para-aminobenzoate synthase subunit I (435 aa)