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glyA protein (Spirosoma linguale) - STRING interaction network
"glyA" - Glycine hydroxymethyltransferase in Spirosoma linguale
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (428 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine (364 aa)
 
  0.995
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (967 aa)
   
 
  0.993
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (517 aa)
   
  0.993
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (295 aa)
 
  0.984
gcvH
Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (127 aa)
   
 
  0.969
Slin_2701
RpiB/LacA/LacB family sugar-phosphate isomerase (143 aa)
   
      0.960
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (193 aa)
 
 
  0.958
Slin_6035
Dihydrolipoamide dehydrogenase (466 aa)
 
  0.955
Slin_5752
Dihydrolipoamide dehydrogenase (466 aa)
 
  0.954
Slin_1729
Threonine aldolase (343 aa)
     
  0.951
Your Current Organism:
Spirosoma linguale
NCBI taxonomy Id: 504472
Other names: S. linguale, S. linguale DSM 74, Spirosoma, Spirosoma linguale, Spirosoma linguale DSM 74, Spirosoma linguale str. DSM 74, Spirosoma linguale strain DSM 74
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