STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cseg_3113DNA ligase D; KEGG: cak:Caul_1769 ATP-dependent DNA ligase; TIGRFAM: DNA ligase D; DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; DNA primase small subunit. (883 aa)    
Predicted Functional Partners:
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.966
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.937
Cseg_3114
KEGG: cak:Caul_2893 hypothetical protein.
       0.762
Cseg_0851
PFAM: protein of unknown function DUF72; KEGG: ccs:CCNA_03207 hypothetical protein.
 
    0.757
Cseg_1878
PFAM: Nucleotidyl transferase; KEGG: cak:Caul_4933 histidinol-phosphate phosphatase family protein.
  
 0.709
Cseg_3110
KEGG: pzu:PHZ_c1134 DNA topoisomerase IB.
 
 
 
 0.698
Cseg_0708
KEGG: ccs:CCNA_03318 cytosolic protein.
 
 
 0.686
Cseg_4133
KEGG: ccs:CCNA_03759 mRNA 3'-end processing factor.
 
 
 0.674
Cseg_1418
KEGG: ccs:CCNA_02090 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase.
  
 
 0.635
Cseg_2122
KEGG: ccs:CCNA_01899 DNA polymerase III, delta' subunit; TIGRFAM: DNA polymerase III, delta prime subunit.
   
 0.635
Your Current Organism:
Caulobacter segnis
NCBI taxonomy Id: 509190
Other names: C. segnis ATCC 21756, Caulobacter segnis ATCC 21756, Caulobacter segnis DSM 7131, Caulobacter segnis IFO 13240, Caulobacter segnis str. ATCC 21756, Caulobacter segnis strain ATCC 21756
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