STRINGSTRING
iscA protein (Alcaligenes faecalis) - STRING interaction network
"iscA" - Iron-sulfur cluster assembly protein IscA in Alcaligenes faecalis
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscAIron-sulfur cluster assembly protein IscA; Forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the HesB/IscA family (107 aa)    
Predicted Functional Partners:
JT27_01535
Scaffolding protein; Derived by automated computational analysis using gene prediction method- Protein Homology (127 aa)
   
  0.921
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily (397 aa)
 
   
  0.909
JT27_01525
Methylglyoxal synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (292 aa)
              0.845
iscR
Fe-S cluster assembly transcriptional regulator IscR; Derived by automated computational analysis using gene prediction method- Protein Homology (158 aa)
   
 
  0.841
JT27_00055
Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method- Protein Homology (482 aa)
   
 
  0.684
JT27_00045
Fe-S cluster assembly protein SufD; Derived by automated computational analysis using gene prediction method- Protein Homology (435 aa)
   
 
  0.681
sufC
Fe-S cluster assembly ATPase SufC; Part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; Derived by automated computational analysis using gene prediction method- Protein Homology (259 aa)
   
 
  0.677
JT27_07590
Glutaredoxin; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the glutaredoxin family. Monothiol subfamily (108 aa)
 
 
  0.614
JT27_00040
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family (415 aa)
   
 
  0.597
lipA
Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (334 aa)
 
   
  0.579
Your Current Organism:
Alcaligenes faecalis
NCBI taxonomy Id: 511
Other names: A. faecalis, ATCC 8750, Alcaligenes faecalis, Alcaligenes sp. BP11, CIP 55.84, CIP 60.80, DSM 30030, IAM 12369, IFO 13111, JCM 20522, JCM 20663, NBRC 13111, NCAIM B.01104, NCIMB 8156, NCTC 11953
Server load: low (21%) [HD]