Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
DNA-binding protein; Derived by automated computational analysis using gene prediction method- Protein Homology (286 aa)
Predicted Functional Partners:
Peptidase C45; Derived by automated computational analysis using gene prediction method- Protein Homology (345 aa)
Uncharacterized protein; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family (441 aa)
Transcriptional regulator; Derived by automated computational analysis using gene prediction method- Protein Homology (278 aa)