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aceK protein (Alcaligenes faecalis) - STRING interaction network
"aceK" - Isocitrate dehydrogenase kinase/phosphatase in Alcaligenes faecalis
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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aceKIsocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (611 aa)    
Predicted Functional Partners:
JT27_04605
Acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method- Protein Homology (393 aa)
              0.853
JT27_04595
Isovaleryl-CoA dehydrogenase; Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA; Derived by automated computational analysis using gene prediction method- Protein Homology (392 aa)
         
  0.803
AFA_11795
Isocitrate lyase; Catalyzes the reversible formation of glyoxylate and succinate from isocitrate; glyoxylate bypass pathway; Derived by automated computational analysis using gene prediction method- Protein Homology (435 aa)
 
   
  0.764
JT27_14900
Isocitrate dehydrogenase [NADP]; Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method- Protein Homology (418 aa)
 
 
 
  0.753
JT27_04590
MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method- Protein Homology (130 aa)
              0.682
JT27_04610
Methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method- Protein Homology (535 aa)
              0.633
JT27_04615
3-methylcrotonyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method- Protein Homology (670 aa)
              0.608
JT27_08145
Methionine synthase; Derived by automated computational analysis using gene prediction method- Protein Homology (1257 aa)
            0.575
ccmE
Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (149 aa)
           
  0.558
fliA
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; Derived by automated computational analysis using gene prediction method- Protein Homology (253 aa)
           
  0.558
Your Current Organism:
Alcaligenes faecalis
NCBI taxonomy Id: 511
Other names: A. faecalis, ATCC 8750, Alcaligenes faecalis, Alcaligenes sp. BP11, CIP 55.84, CIP 60.80, DSM 30030, IAM 12369, IFO 13111, JCM 20522, JCM 20663, NBRC 13111, NCAIM B.01104, NCIMB 8156, NCTC 11953
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