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dnaE protein (Alcaligenes faecalis) - STRING interaction network
"dnaE" - DNA-directed DNA polymerase in Alcaligenes faecalis
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaEDNA-directed DNA polymerase; Catalyzes DNA-template-directed extension of the 3’- end of a DNA strand by one nucleotide at a time; main replicative polymerase; Derived by automated computational analysis using gene prediction method- Protein Homology (1158 aa)    
Predicted Functional Partners:
JT27_05325
Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] (369 aa)
   
  0.977
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5’-3’ exonuclease activity (905 aa)
 
  0.974
JT27_10420
DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method- Protein Homology (808 aa)
 
  0.968
dnaQ
DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3’-5’ exonuclease (241 aa)
   
  0.966
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1370 aa)
   
   
  0.935
JT27_13265
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method- Protein Homology (349 aa)
 
  0.934
JT27_11870
Pyruvate kinase; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the pyruvate kinase family (473 aa)
       
  0.918
JT27_06140
Deoxyguanosinetriphosphate triphosphohydrolase-like protein; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method- Protein Homology (374 aa)
   
   
    0.912
JT27_16520
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method- Protein Homology (353 aa)
     
  0.910
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (141 aa)
     
 
  0.905
Your Current Organism:
Alcaligenes faecalis
NCBI taxonomy Id: 511
Other names: A. faecalis, ATCC 8750, Alcaligenes faecalis, Alcaligenes sp. BP11, CIP 55.84, CIP 60.80, DSM 30030, IAM 12369, IFO 13111, JCM 20522, JCM 20663, NBRC 13111, NCAIM B.01104, NCIMB 8156, NCTC 11953
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