STRINGSTRING
pyrF protein (Alcaligenes faecalis) - STRING interaction network
"pyrF" - Orotidine 5'-phosphate decarboxylase in Alcaligenes faecalis
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrFOrotidine 5’-phosphate decarboxylase; Type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5’-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; Derived by automated computational analysis using gene prediction method- Protein Homology (275 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (224 aa)
 
 
  0.999
carB
Carbamoyl-phosphate synthase large chain; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method- Protein Homology (1080 aa)
   
   
  0.999
carA
Carbamoyl-phosphate synthase small chain; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method- Protein Homology (387 aa)
   
   
  0.999
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP (238 aa)
   
 
  0.958
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (216 aa)
   
 
  0.957
JT27_17860
Aspartate carbamoyltransferase; Catalyzes the conversion of carbamoyl phosphate and aspartate to form N-carbamoyl aspartate; Derived by automated computational analysis using gene prediction method- Protein Homology; Belongs to the ATCase/OTCase family (431 aa)
   
   
  0.953
surE
5’-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5’-monophosphates; Belongs to the SurE nucleotidase family (246 aa)
   
 
    0.905
JT27_05040
5’-nucleotidase; Derived by automated computational analysis using gene prediction method- Protein Homology (333 aa)
         
    0.900
JT27_02555
Allantoinase; Derived by automated computational analysis using gene prediction method- Protein Homology (455 aa)
   
   
  0.854
JT27_01195
Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method- Protein Homology (464 aa)
   
   
  0.854
Your Current Organism:
Alcaligenes faecalis
NCBI taxonomy Id: 511
Other names: A. faecalis, ATCC 8750, Alcaligenes faecalis, Alcaligenes sp. BP11, CIP 55.84, CIP 60.80, DSM 30030, IAM 12369, IFO 13111, JCM 20522, JCM 20663, NBRC 13111, NCAIM B.01104, NCIMB 8156, NCTC 11953
Server load: low (19%) [HD]