STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrLThr operon leader peptide; This protein is involved in control of the biosynthesis of threonine. (21 aa)    
Predicted Functional Partners:
leuL
Leu operon leader peptide; Involved in control of the biosynthesis of leucine.
   
  
 0.878
hisL
His operon leader peptide; Protein involved in histidine biosynthetic process.
   
  
 0.876
trpL
Trp operon leader peptide; This protein is involved in control of the biosynthesis of tryptophan.
      
 0.805
pheL
Leader peptide of chorismate mutase-P-prephenate dehydratase; Protein involved in L-phenylalanine biosynthetic process.
   
  
 0.802
thrA
Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process.
  
  
 0.781
ilvL
ilvGEDA operon leader peptide.
   
  
 0.722
thrC
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L-serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction.
  
  
 0.683
ivbL
ilvB operon leader peptide; This protein is involved in control of the biosynthesis of isoleucine, leucine, and valine.
   
  
 0.667
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L-threonine nor L-serine are substrates of the enzyme.
  
  
 0.614
pyrL
pyrBI operon leader peptide; Protein involved in pyrimidine nucleotide biosynthetic process.
   
  
 0.525
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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