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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiDCrotonobetainyl-coa hydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA (261 aa)    
Predicted Functional Partners:
caiB
Gamma-butyrobetainyl-coa:carnitine coa transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA
 
 
 0.998
caiA
Crotonobetaine reductase subunit ii, fad-binding; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA . The electron donor could be the FixA/FixB complex
 
 0.998
caiC
Putative crotonobetaine/carnitine-coa ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine
 0.997
torS
Hybrid sensory histidine kinase in two-component regulatory system with torr; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His- 860 and Asp-733
   
 
 0.995
evgS
Hybrid sensory histidine kinase in two-component regulatory system with evga; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals
   
 
 0.995
caiE
Stimulator of caid and caib enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD
 
  
 0.983
arcB
Two-component system, ompr family, aerobic respiration control sensor histidine kinase arcb; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576
    
 
 0.947
caiT
L-carnitine:gamma-butyrobetaine antiporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines
 
   
 0.921
rcsC
Two-component system, narl family, capsular synthesis sensor histidine kinase rcsc; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC has also phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division
   
 
 0.905
fixB
Electron transfer flavoprotein alpha subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA
 
 0.880
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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