STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiBGamma-butyrobetainyl-coa:carnitine coa transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA (405 aa)    
Predicted Functional Partners:
caiA
Crotonobetaine reductase subunit ii, fad-binding; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA . The electron donor could be the FixA/FixB complex
 
 0.999
caiD
Crotonobetainyl-coa hydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
 
 
 0.998
caiC
Putative crotonobetaine/carnitine-coa ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine
  
 0.988
caiT
L-carnitine:gamma-butyrobetaine antiporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines
 
   
 0.973
caiE
Stimulator of caid and caib enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD
 
   
 0.950
fixC
Electron transfer flavoprotein-quinone oxidoreductase; Could be part of an electron transfer system required for anaerobic carnitine reduction
 
 
 0.853
fixB
Electron transfer flavoprotein alpha subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA
 
  
 0.842
fixA
Anaerobic carnitine reduction putative electron transfer flavoprotein subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA
 
   
 0.819
caiF
Dna-binding transcriptional activator caif; Potential transcriptional activator of carnitine metabolism
  
   
 0.818
yaaU
Mfs transporter, putative metabolite transport protein; Putative transport protein
 
     0.745
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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