STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
caiACrotonobetaine reductase subunit ii, fad-binding; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA . The electron donor could be the FixA/FixB complex (380 aa)    
Predicted Functional Partners:
caiB
Gamma-butyrobetainyl-coa:carnitine coa transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA
 
 0.999
caiD
Crotonobetainyl-coa hydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
 
 0.998
nuoC
Nadh:ubiquinone oxidoreductase, fused cd subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
   
 0.990
caiC
Putative crotonobetaine/carnitine-coa ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine
 
 0.986
caiT
L-carnitine:gamma-butyrobetaine antiporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines
 
   
 0.978
fixB
Electron transfer flavoprotein alpha subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA
 
 0.958
caiE
Stimulator of caid and caib enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD
     
 0.916
fixA
Anaerobic carnitine reduction putative electron transfer flavoprotein subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA
 
 
 0.916
ydiR
Putative electron transfer flavoprotein, fad-binding subunit; May play a role in a redox process
 
 0.894
fixC
Electron transfer flavoprotein-quinone oxidoreductase; Could be part of an electron transfer system required for anaerobic carnitine reduction
 
   
 0.893
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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