STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rluARibosomal large subunit pseudouridine synthase A; Responsible for synthesis of pseudouridine from uracil- 746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs (219 aa)    
Predicted Functional Partners:
rapA
RNA polymerase-associated protein RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity); Belongs to the SNF2/RAD54 helicase family. RapA subfamily
  
  
 0.960
dusC
tRNA-dihydrouridine(16) synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. DusC specifically modifies U16 in tRNAs; Belongs to the Dus family. DusC subfamily
  
  
 0.886
rimO
Ribosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12
 
 
 0.873
cyaY
Protein CyaY; Iron-binding frataxin homolog; cyaY is expressed; neither knock-out nor overexpression of cyaY in Escherichia coli affects cellular iron content or sensitivity to oxidants; possibly involved in maintaining the intracellular iron pool in a soluble, non-toxic and bio-available form for biosynthetic pathways, while preventing the participation of iron in oxidative damage
      
 0.784
yfiH
Polyphenol oxidase; Multicopper oxidase with polyphenol oxidase activity. Is able to oxidize syringaldazine and 2,2'-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid) (ABTS) in vitro. The physiological substrate and role of YfiH is not known
 
 
 0.782
dusA
tRNA-dihydrouridine(20/20a) synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily
  
  
 0.772
rluE
Ribosomal large subunit pseudouridine synthase E; Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA
 
  
 0.770
abgT
P-aminobenzoyl-glutamate transport protein; Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl- glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule, perhaps a dipeptide, and that it transports p-aminobenzoyl- glutamate as a secondary activity. The physiologi [...]
      
 0.755
croE
Prophage transcriptional regulatory protein; Phage or Prophage Related
      
 0.753
rluB
Ribosomal large subunit pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA
  
  
 0.742
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (11%) [HD]