STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
araAL-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose (500 aa)    
Predicted Functional Partners:
araB
L-ribulokinase; Belongs to the ribulokinase family
 
 0.999
araD
L-ribulose-5-phosphate 4-epimerase AraD; Involved in the degradation of L-arabinose . Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction)
 
 
 0.998
sgbE
L-ribulose-5-phosphate 4-epimerase SgbE; Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). May be involved in the utilization of 2,3-diketo-L-gulonate
 
 
 0.994
ulaF
L-ribulose-5-phosphate 4-epimerase UlaF; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization
 
 
 0.994
xylA
D-xylose isomerase; Belongs to the xylose isomerase family
  
   
 0.950
araE
Mfs transporter, sp family, arabinose:h+ symporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
  
  
 0.920
yagH
CP4-6 prophage; putative xylosidase/arabinosidase; Putative beta-xylosidase
 
  
  0.897
xylB
Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate . Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency . Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates . Has a weak substrate-independent Mg-ATP-hydrolyzing activity
  
  
 0.849
araC
Arac family transcriptional regulator, arabinose operon regulatory protein; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose Functions both as a positive and a negative regulator . In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters In the absence of arabinose, negatively regulates the araBAD operon . Represses its own transcription . Acts by binding directly to DNA
 
   
 0.842
rhaA
L-rhamnose isomerase; Protein involved in carbohydrate catabolic process
      
 0.835
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.