STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
araCArac family transcriptional regulator, arabinose operon regulatory protein; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose Functions both as a positive and a negative regulator . In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters In the absence of arabinose, negatively regulates the araBAD operon . Represses its own transcription . Acts by binding directly to DNA (292 aa)    
Predicted Functional Partners:
araB
L-ribulokinase; Belongs to the ribulokinase family
 
   
 0.959
soxS
Arac family transcriptional regulator, mar-sox-rob regulon activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters
  
 
 
 0.928
marA
Arac family transcriptional regulator, mar-sox-rob regulon activator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF
  
   
 0.922
crp
Camp-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...]
      
 0.901
lacI
Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer
      
 0.888
lacZ
Beta-d-galactosidase; Belongs to the glycosyl hydrolase 2 family
      
 0.876
araE
Mfs transporter, sp family, arabinose:h+ symporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
      
 0.875
rpoD
Rna polymerase, sigma 70 (sigma d) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB
    
 
 0.868
melR
Arac family transcriptional regulator, melibiose operon regulatory protein; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site
  
  
 0.861
marR
Marr family transcriptional regulator, multiple antibiotic resistance protein marr; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site
  
   
 0.856
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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