STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
thiBThiamine/thiamine pyrophosphate/thiamine monophosphate abc transporter periplasmic binding protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import . Binds thiamine, thiamine phosphate and thiamine diphosphate with high affinity (327 aa)    
Predicted Functional Partners:
thiP
Thiamine/thiamine pyrophosphate abc transporter permease; Part of the ABC transporter complex ThiBPQ involved in thiamine import . Probably responsible for the translocation of the substrate across the membrane (Probable)
 
 0.999
thiQ
Thiamine/thiamine pyrophosphate abc transporter atpase; Part of the ABC transporter complex ThiBPQ involved in thiamine import . Responsible for energy coupling to the transport system (Probable)
 
  
 0.998
tonB
Membrane spanning protein in tonb-exbb-exbd transport complex; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to tran [...]
      
 0.799
fhuA
Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane . In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1 The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system
      
 0.679
sgrR
Transcriptional dna-binding transcriptional activator of sgrs srna; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute- binding domain
 
   
 0.658
fetA
Putative iron abc exporter atp-binding subunit feta; Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system
      
 0.647
thiK
Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate
 
   
 0.617
exbD
Membrane spanning protein in tonb-exbb-exbd complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates
      
 0.608
sodC
Superoxide dismutase, cu, zn, periplasmic; Destroys radicals which are normally produced within the cells and which are toxic to biological systems
      
 0.578
exbB
Membrane spanning protein in tonb-exbb-exbd complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB
      
 0.562
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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