| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| allA | yacG | b0505 | b0101 | Ureidoglycolate lyase, releasing urea; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.585 |
| coaE | yacG | b0103 | b0101 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.983 |
| coaE | zapD | b0103 | b0102 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A | Cell division protein zapd; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity | 0.968 |
| gyrA | gyrB | b2231 | b3699 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.999 |
| gyrA | yacG | b2231 | b0101 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.952 |
| gyrB | gyrA | b3699 | b2231 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.999 |
| gyrB | murI | b3699 | b3967 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis | 0.511 |
| gyrB | yacG | b3699 | b0101 | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.979 |
| murI | gyrB | b3967 | b3699 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.511 |
| murI | yacG | b3967 | b0101 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.553 |
| ppdD | yacG | b0108 | b0101 | Putative prepilin peptidase-dependent pilin; Not yet known | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | 0.527 |
| yacG | allA | b0101 | b0505 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | Ureidoglycolate lyase, releasing urea; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate | 0.585 |
| yacG | coaE | b0101 | b0103 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A | 0.983 |
| yacG | gyrA | b0101 | b2231 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...] | 0.952 |
| yacG | gyrB | b0101 | b3699 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...] | 0.979 |
| yacG | murI | b0101 | b3967 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis | 0.553 |
| yacG | ppdD | b0101 | b0108 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | Putative prepilin peptidase-dependent pilin; Not yet known | 0.527 |
| yacG | yacH | b0101 | b0117 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | DUF3300 domain-containing protein YacH; Uncharacterized protein YacH; Putative membrane protein | 0.609 |
| yacG | yacL | b0101 | b0119 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | annotation not available | 0.604 |
| yacG | ybgI | b0101 | b0710 | Dna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase | NIF3 family metal-binding protein; Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides | 0.614 |
STRING Database User Survey
