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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yacGDna gyrase inhibitor yacg; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (65 aa)    
Predicted Functional Partners:
coaE
Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
    
 0.983
gyrB
DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations [...]
    
 
 0.979
zapD
Cell division protein zapd; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
     
 0.960
gyrA
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli . Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes . Relaxes negatively supercoiled DNA in an ATP-independent manner . E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations [...]
   
 
 0.952
ybgI
NIF3 family metal-binding protein; Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides
   
  
 0.614
yacH
DUF3300 domain-containing protein YacH; Uncharacterized protein YacH; Putative membrane protein
      
 0.609
yacL
annotation not available
      
 0.604
allA
Ureidoglycolate lyase, releasing urea; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
      
 0.585
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis
  
   
 0.553
ppdD
Putative prepilin peptidase-dependent pilin; Not yet known
 
     0.527
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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