STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hofCAssembly protein in type iv pilin biogenesis, transmembrane protein; Protein transport protein HofC homolog; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (400 aa)    
Predicted Functional Partners:
hofB
Protein transport protein hofb; Belongs to the GSP E family
 
 0.998
ppdD
Putative prepilin peptidase-dependent pilin; Not yet known
 
  
 0.995
hofQ
Dna catabolic putative fimbrial transporter; Required for the use of extracellular DNA as a nutrient . Could be the porin responsible for transport of DNA across the outer membrane
 
 
 0.983
yggR
Type ii/iv secretion system family protein; Uncharacterized protein YggR; Putative protein transport
 
  
 0.975
pppA
Leader peptidase PppA; Putative enzyme; Not classified
 
  
 0.901
gspE
General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
 
 0.892
gspO
Bifunctional prepilin leader peptidase/ methylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue
 
  
 0.880
gspM
General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
      
 0.826
gspH
Putative general secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
     
 0.801
alpA
CP4-57 prophage; DNA-binding transcriptional activator AlpA; Positive regulator of the expression of the slpA gene . When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease . Part of the cryptic P4-like prophage CP4-57 . Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans- translation
      
 0.784
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.