STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
mrcBPeptidoglycan glycosyltransferase/peptidoglycan dd-transpeptidase mrcb; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (844 aa)    
Predicted Functional Partners:
ftsI
Cell division protein ftsi (penicillin-binding protein 3); Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum Required for localization of FtsN
 
 0.998
lpoB
Outer membrane lipoprotein - activator of mrcb activity; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Stimulates transpeptidase and transglycosylase activities of PBP1b in vitro. May also contribute to outer membrane constriction during cell division, in complex with PBP1b
  
 
 0.998
ftsN
Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable) . Required for full FtsI activity . Required for recruitment of AmiC to the septal ring
  
 0.995
mrdA
Penicillin-binding protein 2, transpeptidase involved in peptidoglycan synthesis; Catalyzes cross-linking of the peptidoglycan cell wall . Responsible for the determination of the rod shape of the cell . Is probably required for lateral peptidoglycan synthesis and maintenance of the correct diameter during lateral and centripetal growth
 
 0.993
lpoA
Outer membrane lipoprotein - activator of mrca activity; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro
  
  
 0.985
mrcA
Penicillin-binding protein 1a, murein transglycosylase and transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits)
  
 
0.974
dacA
Serine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
    
 0.966
dacC
Serine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
    
 0.966
ampH
Peptidoglycan dd-carboxypeptidase/peptidoglycan dd-endopeptidase; Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C-terminal D-Ala- D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG). Also displays a low beta-lactamase activity
     
 0.963
dacD
Serine-type d-ala-d-ala carboxypeptidase (penicillin-binding protein 5/6); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
    
 0.962
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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